THE PERIPHERAL BLOOD CFU-mix: CFU-GM RATIO DURING VERY EARLY REMISSION FROM ACUTE NON-LYMPHOBLASTIC LEUKAEMIA
نویسندگان
چکیده
منابع مشابه
Loss of hematopoietic progenitor cells CFU-GEMM, BFU-E, CFU-Mk, and CFU-GM in the acquired immunodeficiency syndrome (AIDS)?
Hematological abnormalities have been found in the majority of patients with AIDS, in addition to immunological derangements [1]. Furthermore, treatment of opportunistic infections with folic acid antagonists and of neoplasms with cytostatic drugs is frequently complicated by profound thrombocytopenia, neutropenia, and anemia, thus resulting in the withdrawal of the drugs. In the present study ...
متن کاملErythroid progenitors (BFU-e and CFU-e) in acute leukaemia.
Bone marrow erythroid progenitor cells were examined from 50 cases of acute leukaemia and from 20 normal subjects using an in vitro semisolid culture method. Numbers of both primitive erythroid progenitor cells (BFU-e) and later-stage erythroid progenitor cells (CFU-e) were remarkably depressed in patient with acute leukaemia in active phase. However, both BFU-e and CFU-e recovered to within no...
متن کاملVariations in committed stem cells (CFU-GM and CFU-TL) in the peripheral blood of cancer patients treated by sequential combination chemotherapy for breast cancer.
The present work compared the blood variations in some committed stem cells (CSC), and corresponding differentiated WBC during the first three courses of a 6-day sequential chemotherapy given to 16 breast cancer patients for 28 days each. The granulomonocytic and lymphocytic colony-forming unit levels in blood were significantly lowered in cancer patients before treatment. These CSC appeared to...
متن کاملCFU-GM Like Colonies Derived from Embryonic Stem Cells Cultured on the Bone Marrow Stromal Cells
The aim of this study was to isolate mouse embryonic stem cells from late blastocyst stage embryos and to use them as a model system for the study of hematopoietic induction outside the embryo by coculturing of embryonic stem cells with bone marrow stromal cells. Blastocyst stage embryos from pregnant NMRI mice were obtained and cultured for 1-2 days in DMEM medium. The inner cell masses formed...
متن کاملTreatment with Interferon- a Preferentially Reduces the Capacity for Amplification of Granulocyte-Macrophage Progenitors (CFU-GM) from Patients with Chronic Myeloid Leukemia but Spares Normal CFU-GM
The biological target for interferon (IFN)a in chronic myeloid leukemia (CML) is unknown, but one possibility is that amplification of granulocyte-macrophage colony-forming cells (CFU-GM) is reduced. Replating CFU-GM colonies and observing secondary colony formation provides a measure of CFU-GM amplification. Amplification of CML, but not normal, CFU-GM in vitro was significantly inhibited by I...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 1986
ISSN: 0007-1048,1365-2141
DOI: 10.1111/j.1365-2141.1986.tb02974.x